Monitoring the efficiency of a fixed combination of lisinopril and hydrochlorothiazide in the treatment of essential hypertension in duration of 12 weeks – 15 years later

Alen Džubur, Henrieta Hodžić, Aziz Šukalo, Anela Šehić Lihovac, Meliha Mehić, Belma Kapo, Mirjana Mađar-Zec


Objectives: The aim of the study was to test the efficiency, compliance of patients and tolerance to the lisinopril and hydrochlorothiazide treatment.

Methods: We conducted an observational, nonintervention multicentric study in 19 centers in Bosnia and Herzegovina. The study included 147 patients of both sexes diagnosed with essential hypertension who were already ordinated by antihypertensive therapy. The patients were monitored for 12 weeks, i.e. one initial and four control examinations.

Results: The fixed combination of lisinopril and hydrochlorothiazide lowered the values of systolic and diastolic blood pressure for an average of 31/15 mmHg in patients aged 30 to 59 and for an average of 30/10 mmHg in patients over 60 years. The aimed blood pressure values were achieved in 82.31% of patients. The patients’ compliance was evaluated as very good for 87.07% of patients, good for 10.88% of patients and unsatisfactory for 2.04% of patients.

Conclusion: Fixed combination of lisinopril and hydrochlorothiazide is efficient and well tolerable with very good compliance of patients.

Keywords: Lisinopril, hydrochlorothiazide, fixed combination, efficiency, compliance

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