Gastric cancer progression in correlation with distribution and density of T-lymphocytes

Edina Lazović Salčin, Mirsad Babić, Ago Omerbašić, Nina Čamdžić, Svjetlana Radović, Mirsad Dorić, Suada Kuskunović-Vlahovljak, Haris Čampara

Abstract


Objectives: The main objective of the study was to determine whether the distribution fsaand th

Gastric cancer progression in correlation with
distribution and density of T-lymphocytes

e level of

fsa: The main objective of the study was to determine whether the distribution and the level of density of tumor infiltrating CD4+ and CD8+ T-lymphocytes correlates with standard prognostic factors for gastric cancer and whether it has impact on tumor progression.
Methods: The study included 60 tissue samples of operable gastric carcinomas of known regional lymph node status, stained by standard hematoxylin eosin and immunohi

Objectives: The main objective of the study was to determine whether the distribution and the level of density of tumor infiltrating CD4+ and CD8+ T-lymphocytes correlates with standard prognostic factors for gastric cancer and whether it has impact on tumor progression.
Methods: The study included 60 tissue samples of operable gastric carcinomas of known regional lymph node status, stained by standard hematoxylin eosin and immunohistochemical method in order to determine standard pathologic prognostic factors for gastric cancer and to evaluate distribution and density of tumor infiltrating T- lymphocytes.
Results: CD8+ T lymphocytes were predominantly distributed along the margin of carcinoma infiltration, while inside the cancer tissue there were generally few. CD4+ lymphocytes were few in almost all three analyzed zones (margin of carcinoma infiltration, cancer stroma and cancer tissue). The density of CD8+ showed significant positive correlation with CD8+ T lymphocytes within the cancer’s stroma. There was statistically significant difference in density of CD4+ T lymphocytes distributed along the margin of carcinoma infiltration and histological tumor grade, as well as in tumor grade according to Goseki.
Conclusion: CD8+ T lymphocytes are densely arranged along the margin of carcinoma infiltration and they correlate with histological grade of gastric carcinoma.
Keywords: gastric cancer, tumor microenvironment, T- lymphocytes

stochemical method in order to determine standard pathologic prognostic factors for gastric cancer and to evaluate distribution and density of tumor infiltrating T- lymphocytes.
Results: CD8+ T lymphocytes were predominantly distributed along the margin of carcinoma infiltration,

Gastric cancer progression in correlation with
distribution and density of T-lymphocytes

while inside the cancer tissue there were generally few. CD4+ lymphocytes were few in almost all three analyzed zones (margin of carcinoma infiltration, cancer stroma and cancer tissue). The density of CD8+ showed significant positive correlation with CD8+ T lymphocytes within the cancer’s stroma. There was statistically significant difference in density of CD4+ T lymphocytes distributed along the margin of carcinoma infiltration and histological tumor grade, as well as in tumor grade according to Goseki.
Conclusion: CD8+ T lymphocytes are densely arranged along the margin of carcinoma infiltration and they correlate with histological grade of gastric carcinoma.
Keywords: gastric cancer, tumor microenvironment, T- lymphocytes

density of tumor infiltrating CD4+ and CD8+ T-lymphocytes correlates with standard prognostic factors for gastric cancer and whether it has impact on tumor progression.
Methods: The study included 60 tissue samples of operable gastric carcinomas of known regional lymph node status, stained by standard hematoxylin eosin and immunohistochemical method in order to determine standard pathologic prognostic factors for gastric cancer and to evaluate distribution and density of tumor infiltrating T- lymphocytes.
Results: CD8+ T lymphocytes were predominantly distributed along the margin of carcinoma infiltration, while inside the cancer tissue there were generally few. CD4+ lymphocytes were few in almost all three analyzed zones (margin of carcinoma infiltration, cancer stroma and cancer tissue). The density of CD8+ showed significant positive correlation with CD8+ T lymphocytes within the cancer’s stroma. There was statistically significant difference in density of CD4+ T lymphocytes distributed along the margin of carcinoma infiltration and histological tumor grade, as well as in tumor grade according to Goseki.
Conclusion: CD8+ T lymphocytes are densely arranged along the margin of carcinoma infiltration and they correlate with histological grade of gastric carcinoma.
Keywords: gastric cancer, tumor microenvironment, T- lymphocytes


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