Values of fibrinogen in relation to segmental involvement of the venous system in patients with recurrent deep vein thrombosis

Akif Mlačo, Edin Begić, Amer Iglica, Refet Gojak, Nejra Mlačo


Introduction: The occurrence of recurrent venous thrombosis,
despite adequate therapy, is still a topic of research in the scientific
world. The site of thrombosis and the involvement of anatomical
segments represent a significant factor in its occurrence.
Aim: To correlate fibrinogen values with anatomical location
and extent of verified thrombus in patients with recurrent deep
vein thrombosis.
Materials and methods: In the period January 2007-January
2020, 223 patients with recurrent deep vein thrombosis were
analyzed. At admission fibrinogen values were taken.
Results: There was no significant difference in fibrinogen values
in relation to gender (p = 0.842). The difference in mean
fibronogen values between proximal (n = 171) and distal (n =
27 = veins) were not statistically significant (p = 0.326). There
was no difference between the average values of fibrinogen in
relation to the number of segments (1 to 3) (p = 0.298). The
largest number of patients (n = 132) had 2 segments affected,
and fibrinogen values was 4.7 g/L (3.6-7.1 g/L). Male gender
had slightly higher fibrinogen values than females, but without
significance (p = 0.091). The age of the subjects did not
correlate with fibrinogen values ( p = 0.569). Fibrinogen values
according to vein anatomical localization were statistically
non-significant (p = 0.201).
Conclusion: Fibrinogen values were not proved to be an indicator
of anatomical localization and segmental involvement in
patients with recurrent DVT.
Keywords: fibrinogen, venous thrombosis, prognosis.

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