Values of fibrinogen in relation to segmental involvement of the venous system in patients with recurrent deep vein thrombosis

Akif Mlačo, Edin Begić, Amer Iglica, Refet Gojak, Nejra Mlačo

Abstract


Introduction: The occurrence of recurrent venous thrombosis,
despite adequate therapy, is still a topic of research in the scientific
world. The site of thrombosis and the involvement of anatomical
segments represent a significant factor in its occurrence.
Aim: To correlate fibrinogen values with anatomical location
and extent of verified thrombus in patients with recurrent deep
vein thrombosis.
Materials and methods: In the period January 2007-January
2020, 223 patients with recurrent deep vein thrombosis were
analyzed. At admission fibrinogen values were taken.
Results: There was no significant difference in fibrinogen values
in relation to gender (p = 0.842). The difference in mean
fibronogen values between proximal (n = 171) and distal (n =
27 = veins) were not statistically significant (p = 0.326). There
was no difference between the average values of fibrinogen in
relation to the number of segments (1 to 3) (p = 0.298). The
largest number of patients (n = 132) had 2 segments affected,
and fibrinogen values was 4.7 g/L (3.6-7.1 g/L). Male gender
had slightly higher fibrinogen values than females, but without
significance (p = 0.091). The age of the subjects did not
correlate with fibrinogen values ( p = 0.569). Fibrinogen values
according to vein anatomical localization were statistically
non-significant (p = 0.201).
Conclusion: Fibrinogen values were not proved to be an indicator
of anatomical localization and segmental involvement in
patients with recurrent DVT.
Keywords: fibrinogen, venous thrombosis, prognosis.


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References


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