The relationship of peritumoral lymphatic vessel density, marginal adipose tissue invasion and clinicopathological parameters in breast carcinoma

Mirsad Dorić, Edina Lazović Salčin, Nina Čamdžić, Suada Kuskunović-Vlahovljak, Svjetlana Radović, Mirsad Babić


Objective: To investigate a possible association between peritumoral
lymphatic vessel density (LVD) and adipose tissue
invasion (ATI) of cancer cells at the tumor margin and their
correlation with other prognostic parameters in breast cancer,
including lymph node status.
Material and methods: Data of 75 patients with breast carcinoma
were evaluated through combination of peritumoral LVD
and ATI at the tumor margin and compared with clinicopathological
parameters. Peritumoral LVD was assessed by immunostaining
for D2-40 using the Chalkley counting method. Marginal
ATI was defined as either the presence of more than 20
cancer cells in direct contact with the adipose tissue or as the
presence of cancer cells in the adipose tissue.
Cases were evaluated concerning to patient’s age, tumor size
using the TNM staging system, histological type, histological
grade (Nottingham histological score, Elston and Ellis), lymphovascular
invasion, lymph node metastasis, estrogen receptor
(ER), progesterone receptor (PR), HER2/neu status and Ki-67.
Results: The relationship was identified between LVD and
marginal ATI but without statistical significancy (r = -0,207;
p=0,113). There was a significant correlation of the marginal
ATI with Ki-67 expression (r=0,250; p =0.03). The regression
model (all variables according to ATI) showed a significant total
effect (p <0.05), where Ki-67 was an only independent indicator
of ATI.
Conclusion: The present study suggests that adipose tissue invasion
of cancer cells at the tumor margin can be a better
predictive biologic indicator of aggressiveness than peritumoral
lymphatic vessel density in breast carcinoma.
Keywords: breast carcinoma, peritumoral lymphatic vessel density,
marginal adipose tissue invasion.

Full Text:



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